Integrating Transcriptomics, Network Pharmacology, and Machine Learning to Reveal Transglutaminase 2 (TGM2) as a Key Target Mediating Taurocholate Efficacy in Colitis
In conclusion, this study suggests that taurocholate alleviates ulcerative colitis by targeting key genes such as <i>TGM2</i> and modulating immune-related pathways, providing a novel basis for future therapeutic exploration.
Authors
- W. T. K. Cheng (ORCID: https://orcid.org/0009-0008-9961-821X)
- Wenzhe Shi (ORCID: https://orcid.org/0000-0002-9750-6379)
- Junhong Zhu (ORCID: https://orcid.org/0009-0002-6431-6330)
- Guangyao Song (ORCID: https://orcid.org/0000-0002-9901-6074)
- Hao Jia (ORCID: https://orcid.org/0000-0002-4736-0957)
- Lanlan Yi (ORCID: https://orcid.org/0000-0001-9551-3738)
- Sumei Zhao (ORCID: https://orcid.org/0000-0002-4936-0184)
- Yuxiao Xie (ORCID: https://orcid.org/0000-0002-7884-5092)
- Peng-Fei Fu (ORCID: https://orcid.org/0009-0004-2963-8056)
Institutions
- Yunnan Agricultural University (CN)
- Zunyi Normal College (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3390/genes16091024
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Department of Education
- Yunnan Provincial Science and Technology Department
- Major Science and Technology Projects in Yunnan Province