Tranexamic Acid and Systemic Complement Activation in Patients with Traumatic Brain Injury
A pre-hospital 2-gram TXA bolus appears to significantly reduce complement activation and preserve Factor H, a key complement regulatory protein, suggesting TXA's benefit may involve complement modulation. TXA reduced D-dimer, a downstream product of plasmin activation, indicating complement modulation could be due to a plasmin-mediated process. Further studies are needed to determine if this mechanism is plasmin-mediated and applicable to other dosing regimens and non-TBI trauma populations.
Authors
- Angela Sauaia (ORCID: https://orcid.org/0000-0002-8493-389X)
- Christopher D. Barrett (ORCID: https://orcid.org/0000-0001-9720-8155)
- Hunter B. Moore (ORCID: https://orcid.org/0000-0002-5939-3828)
- Russell L. Gruen (ORCID: https://orcid.org/0000-0001-8023-1957)
- Ernest Eugene Moore (ORCID: https://orcid.org/0000-0002-0419-4848)
- Flobater I. Gawargi (ORCID: https://orcid.org/0000-0003-0877-4521)
- Dominik F. Draxler (ORCID: https://orcid.org/0000-0002-6826-0058)
- Robert L. Medcalf (ORCID: https://orcid.org/0000-0001-6885-3892)
- Elizabeth R Maginot
- Isabella M Bernhardt
Institutions
- Australian National University (AU)
- Porter Adventist Hospital (US)
- University Hospital of Bern (CH)
- Monash Medical Centre (AU)
- Denver Health Medical Center (US)
- Hunter College (US)
- Statistical Service (CY)
- University of Colorado Anschutz Medical Campus (US)
- University of Nebraska Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the American College of Surgeons
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1097/xcs.0000000000001606
- Citations
- 1
- Primary Topic
- Blood donation and transfusion practices
- Type
- article
- Field-Weighted Citation Impact
- 2.76