Comparative study of the neuroprotective effects of the drug Cytoflavin and citicoline in a rats model of hemorrhagic stroke

The comparative study of the neuroprotective effects of CF and CC in a rat model of HS revealed that both drugs significantly reduced brain edema and neurological deficits related to sensorimotor and cognitive impairments. CC showed a slight psychostimulatory effect and a shorter duration of action after treatment cessation, while CF exhibited a longer-lasting effect on brain tissue edema, cognitive, and sensorimotor functions after discontinuation. The separate series with only 10-day intravenous CF administration was insufficient to achieve a stable therapeutic effect, suggesting that the continuation of CF treatment with oral forms is required to maintain long-term benefits in the context of experimental HS in rats.