KLB as a potential prognostic biomarker and therapeutic target in colorectal cancer: insights from multi omics and single cell analyses
KLB functions as a potential tumor suppressor in CRC, with diagnostic, prognostic, and therapeutic implications. Its expression in stromal components of the tumor microenvironment suggests a regulatory role in immune response and tumor progression. These findings support KLB as a promising biomarker and therapeutic target for CRC.
Authors
- Wenjin Zhang (ORCID: https://orcid.org/0000-0002-3541-7282)
- Guicheng Wu (ORCID: https://orcid.org/0000-0003-4220-0767)
- Xiaofei Bi (ORCID: https://orcid.org/0009-0008-2283-8564)
- Mei‐Mei Shen
- Chengmei Fang
- Jian Gao
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Chongqing Three Gorges University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1007/s12672-025-03326-0
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing Medical University