Novel Investigation of Hepatitis B Transmission Dynamics via Fractal-Fractional Operators of Variable and Constant Order with Memory Effects

A fractional-order (hepatitis B virus) HBV transmission model is developed using Caputo, Caputo-Fabrizio, and Atangana-Baleanu-Caputo (ABC) operators to capture memory effects and non-local interactions-including asymptomatic carriers and vertical transmission. Existence, uniqueness, positivity, and stability of solutions are established via fixedpoint theorems and Ulam-Hyers criteria. Numerical simulations employ Adams-Bashforth-Moulton and predictor-corrector methods adapted to each fractional derivative. Results show that lowering the fractional order (α < 1) reduces peak viral load, especially with early intervention, but extends infection duration due to slower decay. This fractional modelling framework offers deeper insight into chronic HBV dynamics, vaccination effectiveness, and long-term control strategies.

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Publication Details

Journal
Critical Reviews in Biomedical Engineering
Published
2025-08-29
DOI
https://doi.org/10.1615/critrevbiomedeng.2025059960
Primary Topic
Fractional Differential Equations Solutions
Type
article
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article

Novel Investigation of Hepatitis B Transmission Dynamics via Fractal-Fractional Operators of Variable and Constant Order with Memory Effects

Pawan Kumar Jain, Sumit Gupta, D.D. Khandelwal
Critical Reviews in Biomedical Engineering
Fractional Differential Equations Solutions
article

Novel Investigation of Hepatitis B Transmission Dynamics via Fractal-Fractional Operators of Variable and Constant Order with Memory Effects

Pawan Kumar Jain, Sumit Gupta, D.D. Khandelwal
article en

Abstract

A fractional-order (hepatitis B virus) HBV transmission model is developed using Caputo, Caputo-Fabrizio, and Atangana-Baleanu-Caputo (ABC) operators to capture memory effects and non-local interactions-including asymptomatic carriers and vertical transmission. Existence, uniqueness, positivity, and stability of solutions are established via fixedpoint theorems and Ulam-Hyers criteria. Numerical simulations employ Adams-Bashforth-Moulton and predictor-corrector methods adapted to each fractional derivative. Results show that lowering the fractional order (α < 1) reduces peak viral load, especially with early intervention, but extends infection duration due to slower decay. This fractional modelling framework offers deeper insight into chronic HBV dynamics, vaccination effectiveness, and long-term control strategies.

Critical Reviews in Biomedical EngineeringVol. 54(1)
NIIT University (IN), Institute of Technology Management (IN)
Good health and well-being
Openalex Percentile: Top 73%
Fractional Differential Equations Solutions
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