Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA-NCAM in brain aging and Alzheimer’s disease
These findings highlight distinct regulatory patterns of ES-GluN2B and PSA-NCAM in AD versus normal aging and support a model in which impaired PSA-NCAM buffering facilitates pathological ES-GluN2B signaling and plasticity loss in AD progression.
Authors
- Subhrajit Bhattacharya (ORCID: https://orcid.org/0000-0003-1326-0699)
- Jerome Garcia
- I. Rego Pérez
- Christian Crouzet (ORCID: https://orcid.org/0000-0002-8809-2119)
- Brian P. Carson (ORCID: https://orcid.org/0000-0001-8350-1481)
- Oghenetega E. Imiruaye
- Derick Han (ORCID: https://orcid.org/0000-0001-7550-0438)
Institutions
- University of California, Irvine (US)
- Beckman Laser Institute and Medical Clinic (US)
- University of La Verne (US)
- Keck Graduate Institute (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fnins.2025.1649625
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Wells Fargo
- National Institutes of Health