Evaluation of Preliminary Bronchodilation Effect on Aerosol Delivery from a Dry Powder Inhaler for Patients with Chronic Obstructive Pulmonary Disease with Suboptimal Peak Inspiratory Flow Rate
A significant difference in aerosol drug delivery was observed between optimal and suboptimal groups without a preliminary dose, suggesting that inhaler selection in patients with COPD may need to be individualized on the basis of inspiratory flow capability. Administering a preliminary dose of pMDI<sup>®</sup> before using a DPI minimally affects the suboptimal inhalation through DPI.
Authors
- Hadeer S. Harb (ORCID: https://orcid.org/0000-0003-2259-9686)
- Yasmin M. Madney (ORCID: https://orcid.org/0000-0003-4105-7874)
- Nabila Ibrahim Laz (ORCID: https://orcid.org/0000-0002-7751-4267)
- Mohamed E. A. Abdelrahim (ORCID: https://orcid.org/0000-0003-2209-2674)
- Mohamed Ismail Hassan (ORCID: https://orcid.org/0009-0003-6526-2925)
Institutions
- Beni-Suef University (EG)
- Sinai University (EG)
- Arish University (EG)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1007/s40262-025-01560-x
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund