MiRNA sequencing of platelet and exosome revealed platelet miR-199b-3p as a potential biomarker in lung adenocarcinoma
This study demonstrates that platelet miRNAs are a superior source for liquid biopsy in LAC compared to exosomal miRNAs. We establish hsa-let-7i-5p as a reliable reference gene and identify platelet hsa-miR-199b-3p as a promising non-invasive biomarker for the differential diagnosis of malignant and benign pulmonary nodules, offering a new avenue for the early detection of lung adenocarcinoma.
Authors
- Huaichao Luo (ORCID: https://orcid.org/0000-0002-8632-5230)
- Sisi Yu (ORCID: https://orcid.org/0000-0002-5011-5418)
- Xiaoxia Wen (ORCID: https://orcid.org/0000-0002-7181-5165)
- Yu Liu (ORCID: https://orcid.org/0009-0007-6599-5685)
- Ping Leng (ORCID: https://orcid.org/0000-0002-4019-2153)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan Cancer Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1619448
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42