Complementary role of echocardiography, karyotyping, and chromosomal microarray in congenital cardiac anomalies
Echocardiography remains the cornerstone for the prenatal detection of fetal heart malformations. When combined with karyotyping and CMA, this integrated approach achieves maximal detection of both macroscopic and submicroscopic genomic alterations-particularly in complex cardiac malformations or when extracardiac anomalies coexist-thereby delivering timely, comprehensive genetic information to guide early intervention and tailored perinatal counseling.
Authors
- Jun Yin (ORCID: https://orcid.org/0000-0002-6297-4121)
- Huang‐Tz Ou (ORCID: https://orcid.org/0000-0002-5475-7848)
- Qian Cao (ORCID: https://orcid.org/0000-0002-1732-8817)
- Xiaomeng Zhang (ORCID: https://orcid.org/0000-0002-3291-1904)
- Junru Wang (ORCID: https://orcid.org/0000-0003-1967-5967)
- Bin Zhang (ORCID: https://orcid.org/0000-0001-5305-2494)
- Xia Li (ORCID: https://orcid.org/0000-0002-4348-3175)
- Shuqiong Xu
- Qingsong Wang
- Xianzhong Xiao
- Xianmin Wang (ORCID: https://orcid.org/0009-0005-1155-1718)
- Zhihui Zhao (ORCID: https://orcid.org/0000-0002-8160-9365)
- Tongyong Luo
Institutions
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu Women's and Children's Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fmed.2025.1586161
- Citations
- 1
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35