Fto-mediated m6A modification is essential for cerebellar development through regulating epigenetic reprogramming
In summary, Fto<sup>KO</sup>-induced Kat8 upregulation in an m<sup>6</sup>A-dependent manner resulted in enhanced KAT8 recruitment by IGF2BP3, which improved chromatin accessibility and H4K16ac modification, thereby promoting cerebellar developmental dysfunction.
Authors
- Hoi‐Hung Cheung (ORCID: https://orcid.org/0000-0001-7178-9289)
- Xiujuan Hu
- Boxian Huang (ORCID: https://orcid.org/0000-0001-9913-9077)
- Jiafeng Lu
- Ming Zhang (ORCID: https://orcid.org/0000-0002-8621-9649)
- Hong Li (ORCID: https://orcid.org/0000-0003-2046-9861)
- Jincheng Li (ORCID: https://orcid.org/0000-0002-8363-3916)
- Qingxia Meng (ORCID: https://orcid.org/0009-0005-0666-7425)
- Jing Jiang (ORCID: https://orcid.org/0009-0008-5834-606X)
- Wenjuan Xia
- Chenyue Ding
Institutions
- Chinese University of Hong Kong (HK)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s12929-025-01176-0
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China