Splicing-based biomarkers define a robust multigene classifier for relapsing-remitting multiple sclerosis
Our study introduces a novel, robust AS-based classifier for RRMS and proposes a strategy for transcriptome-based biomarker development in neuroimmunology. However, the relatively small sample sizes within each cohort may limit the generalizability of these findings, warranting larger validation studies to confirm the clinical utility of this biomarker.
Authors
- Rosanna Asselta (ORCID: https://orcid.org/0000-0001-5351-0619)
- Alvino Bisecco (ORCID: https://orcid.org/0000-0002-7202-4445)
- Anita Capalbo (ORCID: https://orcid.org/0000-0002-8399-4463)
- Laura Piccio (ORCID: https://orcid.org/0000-0002-8760-109X)
- Giulia Cardamone (ORCID: https://orcid.org/0000-0002-4176-6710)
- Eduardo Nobile‐Orazio (ORCID: https://orcid.org/0000-0003-2624-8138)
- Valeria Rimoldi (ORCID: https://orcid.org/0000-0002-5598-3986)
- Giulia Soldà (ORCID: https://orcid.org/0000-0003-0972-610X)
- Damiano Verda (ORCID: https://orcid.org/0000-0001-9912-3454)
- Giuseppe Liberatore (ORCID: https://orcid.org/0000-0003-2666-1678)
- Federica Airi (ORCID: https://orcid.org/0000-0001-5135-4229)
- Elvezia Maria Paraboschi (ORCID: https://orcid.org/0000-0002-7935-798X)
- Claudia Cantoni (ORCID: https://orcid.org/0000-0003-1868-4511)
- Valentina Pellicanò
Institutions
- The University of Sydney (AU)
- Barrow Neurological Institute (US)
- Humanitas University (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100312
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00