Anti-HIV and Antimicrobial Activity of 7-Hydrazino-8-hydroxyquinoline-Based Aromatic Hydrazones
Aromatic hydrazones of 7-hydrazino-8-hydroxyquinoline were studied as anti-HIV and antibacterial compounds. A set of the compounds with different aromatic moieties bearing electron-donating and electron-withdrawing substituents has been selected and obtained via the hydrazo coupling and "one-pot" click reaction with aldehydes. The compounds possess activity against both bacterial and fungal targets. Cellular Ku70-inhibiting activity has been found for the series, opening a new class of inhibitors for potential anti-HIV treatment. The compounds display anti-HIV activity in infected cells at submicromolar concentrations. Their low solubility can be overcome by incorporation in water-soluble neutral polyalginate microgels (33% wt load of the compound).
Authors
- С. П. Королев (ORCID: https://orcid.org/0000-0003-2278-4451)
- Vladimir T. Valuev-Elliston (ORCID: https://orcid.org/0000-0003-0365-570X)
- Sergey N. Kochetkov (ORCID: https://orcid.org/0000-0002-7443-6961)
- Anastasia S. Zemskaya (ORCID: https://orcid.org/0000-0002-0332-5105)
- Daria K. Sherman (ORCID: https://orcid.org/0000-0001-9800-9430)
- Lyudmila B. Kalnina (ORCID: https://orcid.org/0000-0002-2702-8578)
- Pavel N. Solyev (ORCID: https://orcid.org/0000-0002-5546-4975)
- Svetlana V. Revtovich (ORCID: https://orcid.org/0000-0003-1594-9334)
- Marina Gottikh (ORCID: https://orcid.org/0000-0002-4613-5096)
- Marat M. Khisamov
- Vasiliy V. Spiridonov
- Yaroslav V. Kozmenko (ORCID: https://orcid.org/0009-0004-3563-6612)
Institutions
- Engelhardt Institute of Molecular Biology (RU)
- Lomonosov Moscow State University (RU)
- Gamalei Institute of Epidemiology and Microbiology (RU)
- D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences (RU)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3390/ijms26178402
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation