Circulating angiotensin-converting enzyme 2 concentration is associated with acute kidney injury and mortality in sepsis
Elevated circulating ACE2 concentrations comprised an independent predictor of ICU mortality, highlighting intricate RAS dynamics in critical illnesses. Low ACE2 concentrations were associated with greater survival, suggesting their potential as an early prognostic indicator.
Authors
- Ching-En Chen
- Ruey‐Hsing Chou (ORCID: https://orcid.org/0000-0003-2081-8419)
- Chun‐Chin Chang (ORCID: https://orcid.org/0000-0001-6402-0754)
- Cheng-Hsueh Wu
- Jiun‐Yu Guo (ORCID: https://orcid.org/0000-0002-7529-7799)
- Po‐Hsun Huang (ORCID: https://orcid.org/0000-0003-1584-6749)
- Ya‐Wen Lu (ORCID: https://orcid.org/0000-0003-0479-1471)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Municipal YangMing Hospital (TW)
- Taipei City Hospital (TW)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1371/journal.pone.0330668
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Health and Welfare
- Shanghai Educational Development Foundation
- Ministry of Science and Technology, Taiwan
- Taipei Veterans General Hospital