Personalized MRI-based characterization of subcortical anomalies in Ataxia-Telangiectasia using deep-learning
Our findings suggest that pallidum, caudate, and cerebellar gray matter are potential targets for novel treatment approaches for A-T. The approach enables identification of subtle tissue anomalies at an individual level, allowing tailored approaches.
Authors
- William Whitehouse (ORCID: https://orcid.org/0000-0001-5207-5731)
- Robert A. Dineen (ORCID: https://orcid.org/0000-0002-9523-2546)
- Denis Parra (ORCID: https://orcid.org/0000-0001-9878-8761)
- Caroline Blanchard (ORCID: https://orcid.org/0000-0002-3055-1511)
- Stefan Pszczółkowski (ORCID: https://orcid.org/0000-0002-5859-3190)
- Catalina Saini
- Cristian Salazar-Vilches
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Pontificia Universidad Católica de Chile (CL)
- Universidad Bernardo O'Higgins (CL)
- Hospital Luis Calvo Mackenna (CL)
- Queen's Medical Centre (GB)
- Nottingham Biomedical Research Centre (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1371/journal.pone.0328828
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- A-T Children's Project
- Action for A-T