A Blockchain-Enhanced Deep Learning Platform for Secure Semantic Alignment and Sharing of Chemical-Biological Data

The integration and sharing of chemical-biological data have become increasingly crucial in advancing research in drug discovery, materials science, and catalysis. However, several key challenges persist, including ensuring accurate semantic alignment, protecting data privacy, and providing reliable decision support. Addressing these challenges is essential to improving the efficiency and security of data-sharing and analysis processes. This paper proposes a comprehensive solution that leverages deep learning for semantic alignment and blockchain technology for secure data sharing. Our platform utilizes natural language processing (NLP) and graph neural networks (GNN) to align heterogeneous chemical-biological datasets, ensuring consistency and completeness across different sources. Additionally, blockchain technology is employed to establish a decentralized and tamper-resistant data-sharing framework, enhancing security and trust among stakeholders. Through extensive experimentation using the Open Catalyst dataset, our results demonstrate the effectiveness of the proposed approach in achieving high-precision data alignment, secure data transactions, and reliable decision support. This work presents an innovative and integrated platform that addresses long-standing challenges in chemical-biological data integration and sharing, paving the way for more efficient and secure collaborative research.

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Publication Details

Published
2025-08-04
DOI
https://doi.org/10.1109/icccn65249.2025.11133806
Primary Topic
Biomedical Text Mining and Ontologies
Type
article
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article

A Blockchain-Enhanced Deep Learning Platform for Secure Semantic Alignment and Sharing of Chemical-Biological Data

Wenzhang Zhang, Sida Huang, Jingxuan Liu, Yuji Dong et al.
Biomedical Text Mining and Ontologies
article

A Blockchain-Enhanced Deep Learning Platform for Secure Semantic Alignment and Sharing of Chemical-Biological Data

Wenzhang Zhang, Sida Huang, Jingxuan Liu, Yuji Dong, Zhiran Wang, Jialuoyi Tan, Xuanji He
article en

Abstract

The integration and sharing of chemical-biological data have become increasingly crucial in advancing research in drug discovery, materials science, and catalysis. However, several key challenges persist, including ensuring accurate semantic alignment, protecting data privacy, and providing reliable decision support. Addressing these challenges is essential to improving the efficiency and security of data-sharing and analysis processes. This paper proposes a comprehensive solution that leverages deep learning for semantic alignment and blockchain technology for secure data sharing. Our platform utilizes natural language processing (NLP) and graph neural networks (GNN) to align heterogeneous chemical-biological datasets, ensuring consistency and completeness across different sources. Additionally, blockchain technology is employed to establish a decentralized and tamper-resistant data-sharing framework, enhancing security and trust among stakeholders. Through extensive experimentation using the Open Catalyst dataset, our results demonstrate the effectiveness of the proposed approach in achieving high-precision data alignment, secure data transactions, and reliable decision support. This work presents an innovative and integrated platform that addresses long-standing challenges in chemical-biological data integration and sharing, paving the way for more efficient and secure collaborative research.

Nanyang Technological University (SG), Xi’an Jiaotong-Liverpool University (CN)
Openalex Percentile: Top 80%
Biomedical Text Mining and Ontologies
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A Blockchain-Enhanced Deep Learning Platform for Secure Semantic Alignment and Sharing of Chemical-Biological Data — Wenzhang Zhang, Sida Huang, et al. · (2025) | TGRS Research Map | TGRS