Helicobacter pylori, peptic ulcer disease, and colorectal cancer: a prospective study with genome-wide interaction analysis and Mendelian randomization
Neither seropositivity for HP nor PUD showed a robust increase on the risk of CRC in a 15-year follow-up. The causal relation of PUD on CRC was significant of East Asian ancestry, not of European ancestry.
Authors
- Dong Wu (ORCID: https://orcid.org/0000-0002-7328-8207)
- Xiaoyin Bai (ORCID: https://orcid.org/0000-0002-9092-7592)
- Sunny H. Wong (ORCID: https://orcid.org/0000-0002-3354-9310)
- Jiarui Mi (ORCID: https://orcid.org/0000-0001-6498-3817)
- Ziqi Wan (ORCID: https://orcid.org/0000-0003-1809-3404)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Sir Run Run Shaw Hospital (CN)
- Tan Tock Seng Hospital (SG)
- National Cancer Center (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Infectious Agents and Cancer
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s13027-025-00686-8
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College
- National Key Research and Development Program of China
- Division of Undergraduate Education