Copper-Catalyzed Electrophilic Amination of Aryl and Pyridylzinc Pivalates Mediated by N-Based Hypervalent Iodine(III) Reagents
We describe a new Cu-catalyzed electrophilic amination of rapidly prepared, air-stable polyfunctional organozinc compounds using hypervalent iodine reagents bearing transferable aryl/alkyl amines. A wide range of aryl, heteroaryl, and alkyl amines were prepared. The mechanism of the reaction was investigated using density functional theory calculations.
Authors
- Fábio M. F. Santos (ORCID: https://orcid.org/0000-0002-9057-9276)
- Ana Cláudia R. Negrão (ORCID: https://orcid.org/0000-0001-7218-8936)
- José Cunha (ORCID: https://orcid.org/0000-0002-6957-0330)
- Pedro M. P. Góis (ORCID: https://orcid.org/0000-0002-7698-630X)
- M. Manuel B. Marques
- Clara S. B. Gomes (ORCID: https://orcid.org/0000-0003-3672-0045)
- Jaime A. S. Coelho (ORCID: https://orcid.org/0000-0002-7459-0993)
- Paul Knochel (ORCID: https://orcid.org/0000-0001-7913-4332)
- Beatriz Dedeiras (ORCID: https://orcid.org/0009-0006-2527-101X)
- Débora Bachin Carvalho
Institutions
- University of Lisbon (PT)
- Institut des Sciences Moléculaires (FR)
- Institute for Medical Research (AR)
- Rede de Química e Tecnologia (PT)
- Ludwig-Maximilians-Universität München (DE)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1021/acs.orglett.5c02881
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Fundação para a Ciência e a Tecnologia