Clinical and Neuropsychological Profiles in People With Chronic Traumatic Encephalopathy Neuropathologic Change
CTE-NC was rare in NACC since 2014. Those with CTE-NC did not differ in clinical symptoms but had higher rates of hippocampal sclerosis, other tauopathies, and TDP-43 inclusions. In this clinicopathologic investigation using in vivo clinical data, although NACC lacks CTE-NC severity/distribution and repetitive head impact data for sensitivity analyses. Larger in vivo clinicopathologic studies are greatly needed to correlate CTE-NC with clinical features.
Authors
- Christian LoBue (ORCID: https://orcid.org/0000-0001-9671-5526)
- Jeff Schaffert (ORCID: https://orcid.org/0000-0002-8842-980X)
- Charles L. White (ORCID: https://orcid.org/0000-0002-3870-2804)
- Hsueh‐Sheng Chiang (ORCID: https://orcid.org/0000-0003-2211-6007)
- John Hart (ORCID: https://orcid.org/0000-0003-3919-8125)
- Nyaz Didehbani (ORCID: https://orcid.org/0000-0001-6121-5759)
- C. Munro Cullum (ORCID: https://orcid.org/0000-0001-9706-5465)
- Niyenth Iyengar
- Richard A. Magill
Institutions
- Beth Israel Deaconess Medical Center (US)
- The University of Texas at Dallas (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1212/wnl.0000000000214012
- Citations
- 2
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.71