Features of Prodromal Parkinson Disease and Dopaminergic Neurotransmission in Community-Dwelling Older Adults
Prodromal nonmotor and motor signs/symptoms of PD are common in community-dwelling older adults. Increased probability of prodromal PD is associated with decreased dopaminergic nerve terminal density of the posterior putamen that is also more asymmetric. Our findings support the use of composite measures of prodromal features to identify individuals at the population level who may be at risk for PD.
Authors
- Mary Ganguli
- Andrea Rosso (ORCID: https://orcid.org/0000-0001-5890-9856)
- Lana M. Chahine (ORCID: https://orcid.org/0000-0003-2521-7196)
- Kelsey Allen
- Sarah K. Royse (ORCID: https://orcid.org/0000-0003-4846-0180)
- Sherri Mosovsky
- Е. И. Ратнер (ORCID: https://orcid.org/0000-0003-0920-4029)
- Brian J. Lopresti
- Caterina Rosano (ORCID: https://orcid.org/0000-0002-0909-1506)
- Anne B. Newman (ORCID: https://orcid.org/0000-0002-0106-1150)
- Gayatri Dholakia (ORCID: https://orcid.org/0000-0002-5575-5799)
- Ian Troidl (ORCID: https://orcid.org/0000-0002-6516-890X)
- Nicolaas Ida Bohnen (ORCID: https://orcid.org/0000-0003-0352-6414)
Institutions
- University of Pittsburgh (US)
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1212/wnl.0000000000214037
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78