First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge
As SARS-CoV-2 circulating variants evolve, it is important to understand the vulnerabilities of these viruses to neutralizing antibodies. Within this manuscript, we describe first-generation antibodies isolated following infection with WA-1 that retain viral neutralization to subsequent Omicron variants by targeting a site of viral vulnerability called the NTD. This work highlights the shifting landscape of SARS-CoV-2 variants and provides mechanistic insights into how antibodies from prior infections may play a role in preventing subsequent SARS-CoV-2 variant infections.
Authors
- Ningbo Jian (ORCID: https://orcid.org/0000-0001-9243-4882)
- Tongqing Zhou (ORCID: https://orcid.org/0000-0002-3935-4637)
- Jaime L. Jensen (ORCID: https://orcid.org/0000-0002-8818-7513)
- Letzibeth Mendez-Rivera
- William W. Reiley (ORCID: https://orcid.org/0000-0001-6383-8343)
- Agnes Hajduczki
- Jeffrey R. Currier (ORCID: https://orcid.org/0000-0002-5696-0268)
- Dominic Paquin‐Proulx (ORCID: https://orcid.org/0000-0003-1407-3414)
- Nelson L. Michael (ORCID: https://orcid.org/0000-0001-5882-5548)
- Vincent Dussupt (ORCID: https://orcid.org/0000-0002-8579-6356)
- Annika Schmid
- Paul V. Thomas (ORCID: https://orcid.org/0000-0002-6772-3997)
- Victoria R. Polonis (ORCID: https://orcid.org/0000-0002-4827-9923)
- Michael Joyce (ORCID: https://orcid.org/0000-0002-6808-7232)
- Shelly J. Krebs (ORCID: https://orcid.org/0000-0003-1136-1760)
- Juhi Arora (ORCID: https://orcid.org/0000-0002-2356-0559)
- Kerri G. Lal (ORCID: https://orcid.org/0000-0002-8970-0198)
- Gabriel L. Smith (ORCID: https://orcid.org/0000-0002-0087-0837)
- Jean‐François Hernandez (ORCID: https://orcid.org/0000-0003-1609-2272)
- Phyllis A. Rees (ORCID: https://orcid.org/0000-0001-9755-8403)
- Isabella Swafford (ORCID: https://orcid.org/0000-0001-8638-2772)
- Rajeshwer S. Sankhala
- I‐Ting Teng (ORCID: https://orcid.org/0000-0002-4704-7100)
- Natalie D. Collins (ORCID: https://orcid.org/0000-0002-8011-9751)
- Mekhala Rao
- Lauren Smith
- Irene León (ORCID: https://orcid.org/0000-0003-2172-8933)
- D B Wasson
- Michelle Zemil McCrea
Institutions
- Trudeau Institute (US)
- Henry M. Jackson Foundation (US)
- Institut de Recherche Vaccinale (FR)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- mBio
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1128/mbio.01036-25
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institute of Allergy and Infectious Diseases