Insights from Tissue Inhibitor of Metalloproteinase-2 Genotypes to Decipher the Genetic Architecture of Childhood Acute Lymphocytic Leukemia Risk
<i>TIMP-2</i> rs8179090, particularly the CC genotype, may serve as a novel biomarker for childhood ALL susceptibility and prognosis, especially in younger and male patients. Genotyping of this polymorphism could support early risk assessment and personalized clinical management in childhood ALL.
Authors
- YUN-CHI WANG
- Chia-Wen Tsai (ORCID: https://orcid.org/0000-0003-0101-5696)
- JEN-SHENG PEI (ORCID: https://orcid.org/0000-0003-1775-4397)
- Da‐Tian Bau (ORCID: https://orcid.org/0000-0002-5504-8656)
- Te‐Chun Hsia (ORCID: https://orcid.org/0000-0003-4297-9918)
- Chao‐Chun Chen (ORCID: https://orcid.org/0000-0002-7028-5609)
- Chung‐Lin Tsai
- HOU-YU SHIH
- Pei‐Chen Hsu
- Wen-Shin Chang
- Huey-En Tzeng
Institutions
- China Medical University (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-08-29
- DOI
- https://doi.org/10.21873/cgp.20532
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical University Hospital
- China Medical University
- Taichung Veterans General Hospital
- Tao Yuan General Hospital, Ministry of Health and Welfare