CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer
CLK2 blocks ferroptosis in colorectal cancer by regulating the HMOX1 and SLC7A11 balance through the KEAP1/NRF2 axis and p53 pathways, providing a strong rationale for targeting CLK2 to treat colon cancer.
Authors
- Bai-Qi Wang (ORCID: https://orcid.org/0009-0000-0866-5187)
- Yu-Ying Liu (ORCID: https://orcid.org/0009-0009-6372-2231)
- Qi-Peng Shu (ORCID: https://orcid.org/0000-0002-8373-4979)
- Yi Liu (ORCID: https://orcid.org/0000-0002-3256-3452)
- Le Li (ORCID: https://orcid.org/0009-0008-6664-995X)
- Run-Lei Du (ORCID: https://orcid.org/0000-0001-7890-9781)
- Xiaodong Zhang (ORCID: https://orcid.org/0000-0002-5137-7145)
- Shaobo Ke (ORCID: https://orcid.org/0000-0002-1790-0764)
- Feng Shi (ORCID: https://orcid.org/0009-0007-5175-7432)
- Hao-Wen Qiu (ORCID: https://orcid.org/0009-0005-4191-0064)
- Hai‐Meng Zhou (ORCID: https://orcid.org/0009-0004-9243-2675)
- Meng Gao (ORCID: https://orcid.org/0000-0002-7323-1630)
Institutions
- Wuhan University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Renmin Hospital of Wuhan University (CN)
- University of South China (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4949
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07