Knockdown of Derlin-1 Represses Cellular Oncogenic Activities in Uveal Melanoma, Enhances its Chemosensitivity to Cisplatin and Reduces Cancer Stem Cell Potential
By analyzing GEO and TCGA datasets combined with <i>in vitro</i> cellular assays, DERL1 was found to be associated with metastasis in uveal melanoma and to be a possible target for further treatment.
Authors
- Jiun-Rung Chen
- Min‐Tsang Hsieh (ORCID: https://orcid.org/0000-0001-7287-9278)
- Hsin‐Chih Yeh (ORCID: https://orcid.org/0000-0003-4113-629X)
- A Liu (ORCID: https://orcid.org/0009-0004-7493-4620)
- Sung‐Chou Li (ORCID: https://orcid.org/0000-0002-3016-9718)
- Cheng‐Yen Wu
- Cheng‐Yi Chen (ORCID: https://orcid.org/0000-0002-0520-346X)
- Wei‐Ting Chen (ORCID: https://orcid.org/0000-0001-8246-0219)
- Pei-Yun Tsai (ORCID: https://orcid.org/0000-0002-6764-6194)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Veterans General Hospital (TW)
Publication Details
- Journal
- Cancer Genomics & Proteomics
- Published
- 2025-08-29
- DOI
- https://doi.org/10.21873/cgp.20538
- Citations
- 1
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- U.S. Department of Veterans Affairs
- Kaohsiung Veterans General Hospital