Metastasis-Initiating Osteosarcoma Subpopulations Establish Paracrine Interactions with Lung and Tumor Cells to Create a Metastatic Niche
Elucidation of key traits of metastasis-competent cancer cells identified cross-talk between osteosarcoma and lung epithelial cells that mediates metastasis and revealed IL1 inhibition as a promising therapeutic strategy for blocking metastasis.
Authors
- Ruben Dries (ORCID: https://orcid.org/0000-0001-7650-7754)
- Maren Cam (ORCID: https://orcid.org/0000-0002-6337-6414)
- Ryan D. Roberts (ORCID: https://orcid.org/0000-0001-5028-744X)
- James B. Reinecke (ORCID: https://orcid.org/0000-0002-6498-7479)
- Matthew V. Cannon (ORCID: https://orcid.org/0000-0002-3035-9490)
- Amy C. Gross (ORCID: https://orcid.org/0000-0002-0123-5085)
- Hélène Le Pommellet (ORCID: https://orcid.org/0000-0003-0534-338X)
- Kelly M. Gutpell (ORCID: https://orcid.org/0000-0003-4808-0655)
- John Hinckley (ORCID: https://orcid.org/0000-0002-3479-1723)
- Sophia Vatelle (ORCID: https://orcid.org/0009-0004-6260-8465)
- Leyre Jimenez Garcia (ORCID: https://orcid.org/0009-0006-7281-1381)
- Berkley E. Gryder (ORCID: https://orcid.org/0000-0003-0130-2302)
- Amanda J. Saraf (ORCID: https://orcid.org/0000-0002-0167-8716)
- Matthew J. Gust (ORCID: https://orcid.org/0009-0009-3159-2559)
Institutions
- Boston University (US)
- Indiana University Health (US)
- Boston Medical Center (US)
- Nationwide Children's Hospital (US)
- Battelle (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Riley Hospital for Children (US)
- Columbus Center (US)
- University School (US)
- Indiana University School of Medicine
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- Indiana University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3360
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09