Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation
Single-cell phenoscaping of more than 1,000 γδ T-cell and patient-derived organoid cultures shows that cancer cells suppress anticancer γδ T-cell cytotoxicity but γδ T cells can use multimodal killing to overcome immunomodulation.
Authors
- John A. Anderson (ORCID: https://orcid.org/0000-0001-7509-3203)
- Marta Barisa (ORCID: https://orcid.org/0000-0001-7846-6810)
- Jahangir Sufi (ORCID: https://orcid.org/0000-0002-4563-5531)
- Xiao Qin (ORCID: https://orcid.org/0000-0002-8738-4187)
- Magdalena Buschhaus (ORCID: https://orcid.org/0000-0002-5705-8997)
- Vivian Li (ORCID: https://orcid.org/0000-0003-2041-0085)
- Angeliki Kanouta (ORCID: https://orcid.org/0009-0007-4742-7350)
- Daniel Fowler (ORCID: https://orcid.org/0000-0002-0966-0983)
- Colin Hutton (ORCID: https://orcid.org/0000-0003-2254-1038)
- Rhianna O’Sullivan (ORCID: https://orcid.org/0009-0005-6128-7601)
- Jonathan Fisher (ORCID: https://orcid.org/0000-0003-3302-2241)
- Ferran Cardoso Rodriguez (ORCID: https://orcid.org/0000-0002-1376-1242)
- Kerry Chester (ORCID: https://orcid.org/0000-0002-3093-3130)
- Christopher J. Tape (ORCID: https://orcid.org/0000-0003-4712-2737)
- Callum Baird Nattress (ORCID: https://orcid.org/0000-0001-9326-3632)
- María Ramos Zapatero (ORCID: https://orcid.org/0000-0003-3873-5347)
- Petra Vlckova (ORCID: https://orcid.org/0000-0001-9633-8492)
- Ewa Basiarz (ORCID: https://orcid.org/0000-0002-2048-954X)
- Ashley A. Campbell (ORCID: https://orcid.org/0000-0003-3604-6935)
Institutions
- Great Ormond Street Hospital (GB)
- The Francis Crick Institute (GB)
- London Cancer (GB)
- Institute of Child Health (IN)
- University College London (GB)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1890
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Wellcome Trust
- UK Research and Innovation
- Cancer Research UK
- National Institute for Health and Care Research
- Great Ormond Street Hospital Charity
- University College London Hospitals NHS Foundation Trust
- Medical Research Council