tRF-21LeuTAA Promotes Oxidative Stress by Altering Glutathione Metabolic Enzymes to Support Prostate Cancer Progression
tRF-21 promotes tumor development by disrupting key metabolic, epigenetic, transcriptional, and post-transcriptional processes that converge on increased oxidative stress, suggesting that targeting this axis may benefit malignancies with elevated tRF-21.
Authors
- Xiuyi Pan (ORCID: https://orcid.org/0000-0003-1918-3209)
- Xueqin Chen (ORCID: https://orcid.org/0000-0002-3165-4280)
- Jinjing Zhong (ORCID: https://orcid.org/0000-0002-9387-967X)
- Ling Nie (ORCID: https://orcid.org/0000-0002-7878-2001)
- Qiao Zhou (ORCID: https://orcid.org/0000-0002-5133-1438)
- Jingyu Qian (ORCID: https://orcid.org/0009-0000-2080-1022)
- Hao Zeng (ORCID: https://orcid.org/0000-0003-0818-8151)
- Ting Yu (ORCID: https://orcid.org/0000-0003-4096-8975)
- Ni Chen (ORCID: https://orcid.org/0000-0002-0628-0723)
- Xiaoyu Guo (ORCID: https://orcid.org/0009-0006-5593-2018)
- Xinyue Zhang (ORCID: https://orcid.org/0000-0001-5848-6646)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0273
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00