Pharmacokinetics of lopinavir/ritonavir in second-line treatment of children with HIV in the CHAPAS-4 trial
Children (3-15 years), weighing at least 14 kg and taking LPV/r in second-line treatment achieve adequate exposure of LPV within limits reported to be safe and well tolerated. These data support the use of a LPV/r-based regimen and the adult formulation of 200/50 mg in children 25-34.9 kg.
Authors
- Veronica Mulenga (ORCID: https://orcid.org/0000-0003-1843-8169)
- Alexander J. Szubert (ORCID: https://orcid.org/0000-0002-2082-0861)
- Chishala Chabala (ORCID: https://orcid.org/0000-0002-5551-5752)
- David Marinus Burger (ORCID: https://orcid.org/0000-0001-7279-2818)
- Hylke Waalewijn (ORCID: https://orcid.org/0000-0002-5135-8729)
- Alasdair Bamford (ORCID: https://orcid.org/0000-0003-4764-229X)
- Victor Musiime (ORCID: https://orcid.org/0000-0001-7472-9054)
- Anne E. M. Kamphuis (ORCID: https://orcid.org/0000-0002-6452-7827)
- Diana M. Gibb (ORCID: https://orcid.org/0000-0002-9738-5490)
- Shafic Makumbi (ORCID: https://orcid.org/0009-0009-2284-9017)
- Vivian Mumbiro
- Angela Colbers (ORCID: https://orcid.org/0000-0002-0389-9934)
- Saskia N. de Wildt (ORCID: https://orcid.org/0000-0002-0502-0647)
- Mutsa Bwakura‐Dangarembizi (ORCID: https://orcid.org/0000-0001-7751-6177)
- Joan Nangiya
- Timo Kiezebrink
Institutions
- Radboud University Nijmegen (NL)
- University of Zimbabwe (ZW)
- University of Cape Town (ZA)
- University of Applied Sciences Utrecht (NL)
- Utrecht University (NL)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- University Teaching Hospital (ZM)
- Radboud University Medical Center (NL)
- University of Zambia (ZM)
- MRC Clinical Trials Unit at UCL (GB)
- Radboud Institute for Molecular Life Sciences (NL)
- Joint Clinical Research Centre (UG)
- University College London (GB)
- Makerere University (UG)
- Medical Research Council (GB)
Publication Details
- Journal
- AIDS
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1097/qad.0000000000004328
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00