Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast Cancer
A localized, injectable cryogel depot successfully induces an inflammatory TME, leading to reduced tumor burden and T-cell exhaustion while avoiding systemic toxicities associated with cytokine delivery.
Authors
- Evan B. Glass (ORCID: https://orcid.org/0000-0002-3169-1866)
- Todd D. Giorgio (ORCID: https://orcid.org/0000-0002-9557-1425)
- Fiona E. Yull (ORCID: https://orcid.org/0000-0003-1636-7942)
- Kristen L. Hoek
- Marjan Rafat (ORCID: https://orcid.org/0000-0002-9444-4379)
- S Goldstein (ORCID: https://orcid.org/0000-0002-6883-7179)
- Paula J. Hurley (ORCID: https://orcid.org/0000-0003-1487-9282)
- Diana Graves (ORCID: https://orcid.org/0000-0002-8195-9613)
- Sydney Ros Henriques
- Laura C. Kennedy (ORCID: https://orcid.org/0000-0001-8958-7909)
- Renjie Jin (ORCID: https://orcid.org/0000-0002-5243-1422)
- Abigail E. Manning
- Benjamin C. Hacker (ORCID: https://orcid.org/0000-0003-1824-8007)
- Ori Z. Chalom
- Young J. Kim (ORCID: https://orcid.org/0000-0001-8434-4561)
- Andrew J. Wilson (ORCID: https://orcid.org/0000-0002-8656-7723)
- Sohini Roy
Institutions
- Johnson & Johnson (United States) (US)
- Regeneron (United States) (US)
- Vanderbilt University (US)
- Vanderbilt-Ingram Cancer Center
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Annals of Biomedical Engineering
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1007/s10439-025-03823-x
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Vanderbilt University
- National Institutes of Health
- Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University