Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study

PH increased type 2 diabetes risk after DPP treatment group was controlled for. That effect was only partially explained by PRS, suggesting that rare gene variants, familial, and environmental factors may contribute to type 2 diabetes risk in people with prediabetes.

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Publication Details

Journal
Diabetes Care
Published
2025-08-29
DOI
https://doi.org/10.2337/dc25-0633
Primary Topic
Genetic Associations and Epidemiology
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article
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article

Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study

Farida Rautaharju, Enrico Cagliero, Alafia Samuels, Ashley Guidi et al.
Diabetes Care
Genetic Associations and Epidemiology
article

Impact of Parental or First-Degree Family History of Diabetes on Diabetes Incidence and Progression During Long-term Follow-up in the Diabetes Prevention Program Outcomes Study

Farida Rautaharju, Enrico Cagliero, Alafia Samuels, Ashley Guidi, Gina McAtee, Erin J. Kazemi, Anna Bowers, Kathy Hattaway, Kenneth G. C. Smith, Kirsten Czech, Rosa Ruiz, Catherine Manus, Nancy J. Aronoff, Sharon M. Hall, John Reusing, Deborah Elsas, John C. Guare, Alan M. Jacobsen, Robin E. Yamamoto, Kali D’Anna, Susan Hagamen, Matthew J. O’Brien, Tara Dacawyma, Ysela Gonzales, Emily B. Schroeder, Sunder Mudaliar, William B. Applegate, Trevor J. Orchard, Wilfred Y. Fujimoto, Vanita R. Aroda, John Spandorfer, Maria Swift, Vickie L. Andre, Helen P. Hazuda, Mary A. Foulkes, Jennifer Arceneaux, Jonathan Scheindlin, Barbara Eberhardt, Vanessa Bradley, Dorothy Gohdes, Clara M. Smith, Asha K. Nair, Raed Imseis, Ellie Horse, Christopher Piromalli, Barbara Fargnoli, Alan R. Shuldiner, Narleen K. Baker-Ladao, Catherine Behrends, Diana Leos, Janet Sewenemewa, Holly Cohn, Darryl Tonemah, Sheila C. Steinke, Jane E. Lee, Sameh Tadros, Beverly Tseng, Jonalle M. Dowden, Nicole Butler, Leslie F. Atler, Janice Freel, Jeong W. Pak, Dace Trence, Catherine S. Poirier, Marsha Simmons, Danielle Powell, Mike Reidy, Ronald Goldberg, Carolyn M. Cantrell, Ann V. Schwartz, Bart Clark, Dana Schweizer, Cherie McCabe, Stacy Rubtchinsky, Gabriel I. Uwaifo, Christopher D. Saudek, Mary Beth Pena, Christine Darwin, Carmen Larreal, Lascelles Kirby, Kathleen M. Kobus, Catherine Benchoff, Maureen Passaro, Lisa Keasler, Henry Mosley, Jill P. Crandall, Sandra T. Foo, José A. Luchsinger, Anna Giannella, Mary Beth Benson, Cheryl F. Smith, Tatiana Walker, Jeanine Roumain, Preethy Kolinjivadi, Steven Poirier, Mary Lou Carrion-Petersen, Edwin B. Fisher, Martia Glass, Yolanda F. Dotson, Roeland J.W. Middelbeek, Adrienne Allen, Doris A. Hernandez-McGinnis, Dawn Jiggetts, Kayla O’Neal, Kristina L. Grimes, Marjorie Bronsord, Lorna Dias, Emily Sullivan, Mimi M. Giles, Constance Pepe, François Aldrich, Chelsea Spencer, Rachel Williams, Fernelle Leandre, Leigh Perreault, Erin O’Kelly Phillips, Valerie Goldman, Marinella Temprosa, ARLETTE C. PERRY, Geraldine Boggs, David Keßler, Margaret Mills, Wendi Wildman, Evette Polczynski, Shandiin Begay, Carol Percy, Jason Kurland, Julia A. St. Amant, Richard F. Hamman, Jeanne Spellman, Cyndy Edgerton, Pamela G. Watson, Toni I. Pollin, Ruthanne Hilbrich, Thomas W. Shields, Cindy Evans, Om P. Ganda, Dione Lenz, Tsedenia Bezabeh, Michelle Yazzie, Susan Roston, Sue Shapiro, Roberta Duncan, James H. Warram, Jonathan Krakoff, Angela Silverman, Marjorie K. Mau, Paul W. Franks, Julia Middendorf, Amber Dragg, Sandra Sangster, Elissa Violino, Lynne Delve, James M. Ignaut, Maureen A. Malloy, Robert Gooding, Joel Bethepu, Simona Szerdi Janesch, Frederick L. Brancati, Charlotte Dodge, Melanie Barkalow, Charlotte Stimpson, Natalie Andon, Ronald T. Ackermann, Valerie Ripley, Joel Zonszein, Larry B. 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Edelman, Celeste C. Thomas, Deborah A. Sanford, Therese Franklin, Stephanie Guimond, Kerry J. Stewart, Sharon D. Jackson, Brent VanDorsten, Lee E. Melancon, Jean Park, Bonnie T. Jortberg, Brittnie Dotson, Angela Hadden, Katherine Horak, Yuping Gao, M. Kaye Kramer, Nisha Grover-Fairchild, Maryanne Nicosia, Marlene Frazier, Lyn M. Kula, Susan Cola, Hermes Flórez, A. V. Lowe, Monica Mullen, Valerie McLymont, Marion S. Kirkman, Norica Tomuta, Nancy Pemberton, Kristi Dohm, Martha Farago, Ellen J. Anderson, Mark R. Burge, Elizabeth A. Walker, Javiva Horne, Nnenna Agharanya, Carlos Lorenzo, Basma Fattaleh, Ted Ganiats, Elise Zimmerman, Kim Kelly-Dinham, Louise E. Ingraham, Linda Semler, Jacqueline M. Ghahate, Deloris Heard, F. Xavier Pi‐Sunyer, Khan Akbar, Sujata Jinagouda, Ebenezer A. Nyenwe, Renee Wiggins, Susie M. Kelly, Pamela A. Schinleber, Susan Harrier, Robert R. Henry, Stacey Kloiber, Patrice G. Saab, Lisa Chai, Mae K. Isonaga, David S. Schade, LeeLana Thomas, Maria Rosario G. Araneta, Karwyn S. Adams, Kathy Abbott, Beverly D. Porter, Elsayed Z. Soliman, Pharis Mohideen, José C. Florez, Bertha Veciana, George A. Bray, Robert J. Roy, Louann Harris, Marizel Quitingon, Kristy Bondi, Richard S. Katz, Elaine Grassa, Caitlin E. Carter, Robert L. Hanson, Sarah Bassiouni, Arleen F. Brown, Andrea M. Kriska, Amitha Domalpally, Karen Kavena, William C. Knowler, Samia Das, Claudia Conzues, Dawn Myers, Linda M. Delahanty, Alla Sapozhnikova, Melvin Prince, Marycie Lamkin, Wylie McNabb, Amy D. Otto, Michelle Marr, Harelda Anderson, Alicia Noel, Nestoras Mathioudakis, Heather Baumhauer, Cheryl K.H. Johnson, Karen Vejvoda, Tina Brenneman, Kimberly Loman, Erma Levy, Susan Reamer, Ashley H. Tjaden, Alicia Greene, Angela Goldstein, Tonya Jenkins, Crystal Duncan, Donald S. Williamson, Avnisha Patel, Michael Brändle, Naomi Katzir, Betty M. Kennedy, Kathleen Colleran, David D. McPherson, Preethi Srikanthan, Marie‐France Hivert, Valarie Weinzierl, Edwin S. Fineberg, Gregory M. 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Perry, Beverly Williams-Cleaves, Juliet Sanguily, Debra Waters, Margaret Kocal, Catherine M. Champagne, Judith G. Regensteiner, William H. Polonsky, Roylen S. Kaskalla, Blandine Laferrère, Anthony A. Killeen, Nopporn Thangthaeng, Dana Dabelea, Lori Lambert, Judith Wylie‐Rosett, Michael Bryer‐Ash, Wendy Benz, Kellie A. Smith, Boyd E. Metzger, Ronald J. Prineas, Liana K. Billings, Uzoma N. Ibebuogu, Helen Chong, Donna H. Ryan, Elizabeth M. Venditti, Sharon Cappelli, Kelly J. Acton, Gaye Koenning, Miranda Smart, Kisha L. Pinner, Renee Reinhart, Medha N. Munshi, Ryan Gilligan, Ralph Beddow, Sunder Mudaliar, Elizabeth Stamm, Maria G. Montez, Andy Ewen, Maria Budget, Katherine V. Williams, Ellie Corkery, Claire Hemphill, B. Ned Calonge, Lindsery Gurry, Wayman W. Cheatham, Jerrold M. Olefsky, David Altshuler, Ping Zhang, Ling Chen, Christine Lee, Mohammed F. Saad, Christine Stevens, Lisa L. Smith, Michelle Chan, Caren G. Solomon, Heather J. Hoffman, David M. Nathan, Morton B. Brown, Tara Wilson, William H. Herman, Patrick J. Boyle, Patricia V. Nash, Rosalyn Barber, Lynne C. Lichtermann, David W. Price, Richard F. Arakaki, Kieren J. Mather, Elizabeth Barrett‐Connor, David A. Ehrmann, Enrique Caballero, Carissa M. Smith, April Thomas, James Rochon, Barry J. Goldstein, Robert H. Knopp, Jeff Curtis, Marsha Miller, Brenda K. Montgomery, Barbara Blodi, Greg Strylewicz, A. Raymond, Kristin David, Nancy Rowland, Diane Larsen, Tracy Jones, Charlton Wilson, R. Eastman, Sarah Fowler, Dan O’Leary, Richard P. Donahue, Fannie Smith, Julie A. Nelson, Jeffery J. Zachwieja, Amer Rassam, Carolyn King, Adrian Casillas, Laurie Bissett, Richard R. Rubin, Paris Roach, Charles Campbell, Kenneth S. Polonsky, Sanford Garfield, Kathleen Jablonski, Raymond P. Bain, Sherita Hill Golden, Tonya Taylor, Jean Louise M. Smith, Madelyn L. Wheeler, Mary E. Murphy, Rhea Mundra, Ronald P. Danis, Larry D. Hubbard, Steve Jones, Jennifer C. Lovejoy, Steven M. Haffner, Wendy Grant, John J. Albers, Julio V. Santiago, Abbas E. Kitabchi, Tina Morgan, Deloris Johnson, Pentti M. Rautaharju, Debra Clark, Harriet Ricks, Thomas Pitts, Deanna Gabrielson, Helen Seagle, Carmen Pal, Jadell Mendez, Susan Hensley, Debra Rubinstein, Lindsay Doherty, Edward W. Lipkin, Adrienne Gottlieb, Merry Jackson, Noemi Neira, Bonnie Gillis, Richard T. Tulley, Robert R. Moran, F. José, Anne Murillo, C Di Muro, Julie Hu, Brenda A. Broussard, Yong Ma, Emily Tsai
article en

Abstract

PH increased type 2 diabetes risk after DPP treatment group was controlled for. That effect was only partially explained by PRS, suggesting that rare gene variants, familial, and environmental factors may contribute to type 2 diabetes risk in people with prediabetes.

Diabetes CareVol. 48(10)
Johns Hopkins University (US), University of Tennessee Health Science Center (US), University of California, Los Angeles (US), University of California San Diego (US), The Coordinating Center (US), VA Puget Sound Health Care System (US), University of Baltimore (US)
National Institutes of Health
Openalex Percentile: Top 75%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
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