UTILIZATION OF BIOMIMETIC STRATEGIES IN THE SYNTHESIS OF LEVODOPA

This review explores the utilization of biomimetic principles in levodopa synthesis, emphasizing enzymatic catalysis, bio-inspired molecular design, and green chemistry approaches.Key methodologies include the application of tyrosinase and laccase enzymes for regioselective hydroxylation of L-tyrosine and phenylalanine analogs, as well as the use of cofactor-recycling systems to enhance reaction efficiency.Additionally, chemoenzymatic hybrid strategies that emulate metabolic pathways have further streamlined levodopa production while minimizing the use of toxic reagents and waste generation.These approaches not only align with sustainable pharmaceutical manufacturing but also enhance the scalability and affordability of levodopa production.The review underscores the transformative potential of biomimicry in advancing drug synthesis, presenting a model for future applications in green and efficient drug development.