Functional and taxonomic dysbiosis of the supragingival plaque metagenome in Behçet’s disease
This high-resolution metagenomic analysis reveals profound oral microbiome dysbiosis in Behçet's Disease, characterized by altered diversity, a distinct taxonomic signature enriched with pathobionts, and significant functional shifts. These comprehensive microbial alterations are implicated in contributing to the local and systemic inflammatory processes driving BD pathogenesis, offering potential avenues for diagnostic biomarkers and targeted therapies.
Authors
- Chompak Khamwachirapitak (ORCID: https://orcid.org/0000-0003-4718-0208)
- Nisachon Siripaiboonpong
- Chatkoew Boriboonhirunsarn
- Pitipol Choopong (ORCID: https://orcid.org/0000-0001-8857-8488)
- Annop Krasaesin (ORCID: https://orcid.org/0000-0002-1102-9162)
- Rangsini Mahanonda (ORCID: https://orcid.org/0009-0007-2156-6977)
- Supreda Suphanantachat Srithanyarat (ORCID: https://orcid.org/0000-0001-6272-8169)
- George Pelekos (ORCID: https://orcid.org/0000-0003-1917-1988)
- Thantrira Porntaveetus (ORCID: https://orcid.org/0000-0003-0145-9801)
- Paswach Wiriyakijja (ORCID: https://orcid.org/0000-0002-2340-517X)
- Wasawat Sermsripong
- Thanyarat Sapthanakorn
- Pimchanok Sutthiboonyaphan
Institutions
- Siriraj Hospital (TH)
- Chulalongkorn University (TH)
- Mahidol University (TH)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1080/20002297.2025.2552165
- Citations
- 2
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- Health Systems Research Institute