Establishment and molecular profiling of a <scp>PDX</scp> model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic <scp>MSH6</scp> variant

We report an extensive molecular profile of a CMMRD patient, and the developed PDX model can be applied to explore new therapeutic approaches for CMMRD-associated brain tumors.

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Publication Details

Journal
Animal Models and Experimental Medicine
Published
2025-08-29
DOI
https://doi.org/10.1002/ame2.70069
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

Establishment and molecular profiling of a PDX model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic MSH6 variant

Mirella Baroni, Maurício Gustavo Ieiri Yamanari, Sílvia Teixeira, Felipe Antônio de Oliveira Garcia et al.
1 links
Animal Models and Experimental Medicine
Genetic factors in colorectal cancer
article

Establishment and molecular profiling of a PDX model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic MSH6 variant

Mirella Baroni, Maurício Gustavo Ieiri Yamanari, Sílvia Teixeira, Felipe Antônio de Oliveira Garcia, Bruna Minniti Mançano, Gustavo Ramos Teixeira, Rui Manuel Reis, Iara Viana Vidigal Santana, Augusto Perazzolo Antoniazzi, Luciane Sussuchi da Silva, Eric Allison Philot, Murilo Bonatelli, Flavia Paula, Lucas Dias Lourenço, Xiaobin Xing, Adrian Willig, Carlos Almeida, Zhenyu Xu, André Escremim de Paula, Daniel Antunes Moreno
article en

Abstract

We report an extensive molecular profile of a CMMRD patient, and the developed PDX model can be applied to explore new therapeutic approaches for CMMRD-associated brain tumors.

Animal Models and Experimental MedicineVol. 8(11)
Centro Universitário da Fundação Educacional de Barretos (BR), Hospital de Câncer de Barretos (BR), Instituto Barretos de Tecnologia (BR), Sophia Genetics (Switzerland) (CH), Clinical Academic Center of Braga (PT), University of Minho (PT)
Hospital de Câncer de Barretos, Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico
Openalex Percentile: Top 67%
Genetic factors in colorectal cancer
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