Establishment and molecular profiling of a <scp>PDX</scp> model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic <scp>MSH6</scp> variant
We report an extensive molecular profile of a CMMRD patient, and the developed PDX model can be applied to explore new therapeutic approaches for CMMRD-associated brain tumors.
Authors
- Mirella Baroni (ORCID: https://orcid.org/0000-0002-1622-9606)
- Maurício Gustavo Ieiri Yamanari (ORCID: https://orcid.org/0000-0002-8394-8029)
- Sílvia Teixeira (ORCID: https://orcid.org/0000-0002-2462-8535)
- Felipe Antônio de Oliveira Garcia (ORCID: https://orcid.org/0000-0003-3770-5672)
- Bruna Minniti Mançano (ORCID: https://orcid.org/0000-0001-7489-4906)
- Gustavo Ramos Teixeira (ORCID: https://orcid.org/0000-0001-8363-3513)
- Rui Manuel Reis (ORCID: https://orcid.org/0000-0002-9639-7940)
- Iara Viana Vidigal Santana (ORCID: https://orcid.org/0009-0007-5137-3754)
- Augusto Perazzolo Antoniazzi (ORCID: https://orcid.org/0000-0003-4766-6806)
- Luciane Sussuchi da Silva (ORCID: https://orcid.org/0000-0002-7470-4655)
- Eric Allison Philot (ORCID: https://orcid.org/0000-0002-0642-4467)
- Murilo Bonatelli (ORCID: https://orcid.org/0000-0002-7607-5119)
- Flavia Paula (ORCID: https://orcid.org/0009-0001-9236-990X)
- Lucas Dias Lourenço
- Xiaobin Xing
- Adrian Willig
- Carlos Almeida (ORCID: https://orcid.org/0000-0002-1469-0124)
- Zhenyu Xu (ORCID: https://orcid.org/0000-0002-6802-8443)
- André Escremim de Paula
- Daniel Antunes Moreno
Institutions
- Centro Universitário da Fundação Educacional de Barretos (BR)
- Hospital de Câncer de Barretos (BR)
- Instituto Barretos de Tecnologia (BR)
- Sophia Genetics (Switzerland) (CH)
- Clinical Academic Center of Braga (PT)
- University of Minho (PT)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1002/ame2.70069
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hospital de Câncer de Barretos
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico