Characterization of <i>bla</i>OXA-542-mediated carbapenem resistance in <i>Acinetobacter baumannii</i>
The results demonstrated that blaOXA-542 confers resistance to carbapenem and penicillin in A. baumannii and Escherichia coli while exhibiting no significant impact on cephalosporins. The ability of blaOXA-542 to hydrolyze meropenem was further confirmed by modified carbapenem inactivation assay (mCIM). Expression of blaOXA-542 in E. coli BL21 showed no significant growth rate alteration. Comparative analysis of the blaOXA-542 genetic environment revealed a close association with Acinetobacter pitti. This study reports the emergence of blaOXA-542-mediated carbapenem and penicillin resistance in a novel A. baumannii lineage (ST2795Pas/ST3464Oxf), highlighting the urgent need for rational antibiotic use against specific pathogens.
Authors
- Feng Lü (ORCID: https://orcid.org/0000-0002-5695-6015)
- Jingchen Hao
- Cuicui Liu (ORCID: https://orcid.org/0000-0001-5112-2858)
- Jian Hu (ORCID: https://orcid.org/0000-0002-8349-6595)
- Guocai Li (ORCID: https://orcid.org/0000-0001-5857-4646)
- Chengjie Ji (ORCID: https://orcid.org/0000-0003-1730-6367)
- Na Li (ORCID: https://orcid.org/0000-0002-8754-2851)
- Ping Chen (ORCID: https://orcid.org/0000-0002-1195-3961)
- Yuan Chen (ORCID: https://orcid.org/0000-0001-9059-3839)
- Yue Xu (ORCID: https://orcid.org/0000-0001-7672-9170)
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Fuyang City People's Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Yixing People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/jac/dkaf311
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China