Circadian disruption induces cognitive impairment through tryptophan-5-HT metabolic pathway dysregulation

Circadian disruption downregulated key rate-limiting enzymes in the tryptophan metabolism 5-HT pathway, decreasing 5-HT levels and leading to cognitive impairment. These findings offer new insights into the understanding of cognitive impairment caused by circadian disruption and its metabolic mechanisms in mice. Statement of Significance This study is significant because it simulates the circadian disruption induced by chronic irregular light exposure. A comprehensive evaluation of the impact of circadian disruption on cognitive function was conducted, and metabolomics technology was used to elucidate the metabolic alterations that occur during the process of cognitive impairment linked to circadian disruption. Our research findings underscore the significance of the tryptophan metabolic pathway in the process of cognitive impairment induced by circadian disruption and reveal that the downregulation of tryptophan-5-HT represents a pivotal metabolic change. These findings offer a novel perspective and preventive strategies for neurological disorders triggered by circadian disruption.