A case-control study on cryopreserved versus non-cryopreserved strategies for autologous hematopoietic cell transplantation in multiple myeloma
Background: Autologous hematopoietic cell transplantation (aHCT) is a standard treatment for Multiple Myeloma (MM). The classic practice is with cryopreservation of the peripheral blood stem cells (PBSC) in the period from collection to infusion, but non-cryopreserved storage at 4oC has demonstrated to be feasible and safe. Methods: Here we present a retrospective, case-control study comparing the outcomes in terms of engraftment in two centers in Uruguay, one with cryopreservation (Hospital Británico-HB) and the other with 4oC storage (Hospital Maciel-HM). Results: 69 patients were included during Oct 15, 2018 and Dec 23, 2023. Median age was 60 years old (32-72). The median of collected PBSC was 9.0 x 106/kg (range 2.7 - 32.3), and the median of PBSC infused was 5.4 x 106/kg, (range 2.7 - 10.8). The time to neutrophil engraftment was 10 days (range 6-12) in HM and 9 days (range 7-12) in HB (p=0.38). The time for platelet engraftment was 20 days (range 17-25) in HM and 19 days (range 15-30) in HB (p=0.14). There were no graft failures, and no treatment-related mortality was observed at 100 days. Conclusions: Both cryopreserved and non-cryopreserved strategies appear to achieve similar outcomes in terms of engraftment and safety. Non-cryopreservation could be a way to improve affordability and accessibility to aHCT in MM, particularly in resource-limited areas.
Authors
- Byron Figueroa (ORCID: https://orcid.org/0009-0001-2793-7827)
- Carla Ambrosini
- Pablo Muxí (ORCID: https://orcid.org/0000-0001-5985-1457)
- Virginia Marcalain (ORCID: https://orcid.org/0000-0001-6226-1466)
- V. Moraes (ORCID: https://orcid.org/0000-0003-3561-6369)
- Melanie Isern (ORCID: https://orcid.org/0009-0000-3905-1073)
- Juan Ferrari (ORCID: https://orcid.org/0000-0001-6884-032X)
- Cristina Otero (ORCID: https://orcid.org/0000-0002-3283-4187)
- Gabriel Borelli (ORCID: https://orcid.org/0000-0003-3217-5684)
- Rosanna De Giuda (ORCID: https://orcid.org/0000-0001-8841-6198)
- Regis Gai (ORCID: https://orcid.org/0000-0001-8890-8571)
- Victoria Remedi (ORCID: https://orcid.org/0000-0002-5113-0951)
- Ana Inés Landoni (ORCID: https://orcid.org/0000-0001-8089-4515)
- María Mori (ORCID: https://orcid.org/0000-0003-1392-1741)
- Silvia Pierri (ORCID: https://orcid.org/0000-0003-3843-5299)
- Victoria Irigoín (ORCID: https://orcid.org/0000-0002-6816-666X)
- Sebastián Galeano (ORCID: https://orcid.org/0000-0002-8048-2892)
- Claudia Martinez (ORCID: https://orcid.org/0000-0001-9301-9453)
- Eloísa Riva (ORCID: https://orcid.org/0000-0002-4750-034X)
- Carolina Oliver (ORCID: https://orcid.org/0000-0002-7782-2024)
- Silvia Pisano
- Romina Urrutia (ORCID: https://orcid.org/0000-0001-9276-8321)
- Laura Bello (ORCID: https://orcid.org/0000-0003-0317-9264)
- Laura Baladé Martínez
- M. Ferrando (ORCID: https://orcid.org/0000-0002-3305-0472)
- Martina Perdomo (ORCID: https://orcid.org/0000-0003-3399-266X)
- Escarlata López
- Raúl Gabus (ORCID: https://orcid.org/0000-0003-2213-7246)
- Jhon Prieto (ORCID: https://orcid.org/0000-0002-8103-1989)
- Alberto Vásquez (ORCID: https://orcid.org/0009-0006-2142-5798)
- Camila Guidali (ORCID: https://orcid.org/0000-0003-1033-7726)
- Lourdes Viano (ORCID: https://orcid.org/0000-0002-5827-2821)
- Analía Olivera (ORCID: https://orcid.org/0000-0002-3824-1673)
- Carina Lamela (ORCID: https://orcid.org/0000-0002-2387-3248)
Institutions
- Hospital Británico (UY)
- Hospital Maciel (UY)
Publication Details
- Journal
- JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY
- Published
- 2025-08-29
- DOI
- https://doi.org/10.46765/2675-374x.2025v6n1e251
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00