Applicability of guideline-informing lipid-lowering clinical trials to contemporary real-world patients with atherosclerotic cardiovascular disease
Eligibility of real-world ASCVD patients for lipid-lowering RCTs varied substantially across trials and ASCVD subtypes. Despite differences in clinical characteristics, trial-eligible and ineligible patients generally had comparable outcomes, suggesting that guideline-informing lipid-lowering trials are broadly representative of contemporary real-world ASCVD patients.
Authors
- Charlotte Koopal (ORCID: https://orcid.org/0000-0003-1487-1635)
- Pauline C E Schuitema
- Frank L.J. Visseren (ORCID: https://orcid.org/0000-0003-3951-5223)
- Manon C. Stam‐Slob (ORCID: https://orcid.org/0000-0003-2145-9446)
Institutions
- Utrecht University (NL)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- European Heart Journal - Quality of Care and Clinical Outcomes
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1093/ehjqcco/qcaf091
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Universiteit Utrecht