Combined extract evaluation of hydroalcoholic leaf extracts in evaluating the hepatoprotective efficacy of Sphaeranthus amaranthoides and Paerida foetida against CCl4-induced hepatotoxicity in wistar rats

Liver disease is becoming the most common cause of death all over the world. Each year 5.9 % of global death is associating with alcohol-related liver disease (ALD), The current study focuses on readily available natural resources. S.amaranthoides and P. foetida plants hydroethanolic extracts demonstrated a significant hepatoprotective potential on CCl4-induced hepatotoxic Wistar rats, Alteration of serum SGOT, SGPT and Alkaline Phosphatase concentration caused by CCl4 administration was recovered by using combined plant extracts. Treatment with 500mg/kg of both plants' hydroethanolic extracts, Sphaeranthus amaranthoides and Paerida foetida, resulted in a significant decrease in the levels of ALT, AST, ALP, total protein, total bilirubin, as well as a significant increase in the levels of MDA and GSH when compared to the disease control group. When compared to the standard group given silymarin at a dose of 10mg/kg body weight, histopathological studies revealed a good hepatoprotective effect. Combined plant extracts have shown a potential impact, may be due to presence of flavonoids and phenolic content. As both plants are edible, they are safe and effective.