Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis
Our findings support investigation of HSPB1 as both a biomarker and therapeutic target in ALD. Furthermore, this work demonstrates that anti-HSPB1 antibody is a rational approach to targeting HSPB1 with the potential to block inflammation and protect hepatocytes, without inactivating host defense.
Authors
- Megan R. McMullen (ORCID: https://orcid.org/0009-0007-6020-7125)
- Srinivasan Dasarathy (ORCID: https://orcid.org/0000-0003-1774-0104)
- Vai Pathak
- Daniela Allende (ORCID: https://orcid.org/0000-0001-9868-8269)
- Laura E. Nagy (ORCID: https://orcid.org/0000-0002-0580-2809)
- Jeannette S. Messer (ORCID: https://orcid.org/0000-0002-5072-3835)
- Adam M. Schmitt (ORCID: https://orcid.org/0000-0002-7723-0651)
- Vartika Srivastava (ORCID: https://orcid.org/0000-0002-8636-3413)
- David Streem (ORCID: https://orcid.org/0000-0001-5804-7598)
- Emily Huang (ORCID: https://orcid.org/0000-0002-9558-7814)
- Jaividhya Dasarathy
- Daniel Miller Rotroff (ORCID: https://orcid.org/0000-0003-0553-3220)
- Nicole Welch (ORCID: https://orcid.org/0000-0002-4655-5146)
- Chelsea Finney
- Annette Bellar
- Anne-Marie C. Overstreet (ORCID: https://orcid.org/0009-0008-6701-1640)
- Raveena Vij
- McKenzie Burge
- K E Hunter
- Douglas Czarnecki
- B. Ben Koff
Institutions
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Community Health Systems - Lutheran Hospital (US)
- MetroHealth Medical Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1097/hc9.0000000000000768
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00