Cell-specific expression and signaling of glucocorticoid receptor isoforms over time in critically ill patients with a low inflammatory response
PMNs show reduced GCR-α/β/γ with preserved GILZ, while PBMCs maintain GCR-α/β/γ but upregulate GCR-P and DUSP1. These findings highlight divergent GC responsiveness between innate and adaptive immune cells, with implications for cortisol's role in immune regulation during critical illness and may reflect cell-specific effects driven by changes in glucocorticoid receptor signaling.
Authors
- Vasileios Issaris (ORCID: https://orcid.org/0000-0001-6107-9400)
- Nikolaos S. Lotsios (ORCID: https://orcid.org/0000-0002-7194-3976)
- Charikleia S. Vrettou (ORCID: https://orcid.org/0000-0002-1067-8849)
- Ioanna Dimopoulou (ORCID: https://orcid.org/0000-0002-2219-7292)
- Marinella Tzanela
- Chrysi Keskinidou (ORCID: https://orcid.org/0000-0002-4047-3588)
- Kostas A. Papavassiliou (ORCID: https://orcid.org/0000-0001-9620-745X)
- Dimitra A. Vassiliadi (ORCID: https://orcid.org/0000-0002-3403-8977)
- Efthymia Botoula
- Anastasia Kotanidou
- Alice G. Vassiliou (ORCID: https://orcid.org/0000-0003-4984-0476)
- Athanasios G. Papavassiliou (ORCID: https://orcid.org/0000-0001-5803-4527)
- Asimenia Halioti
- Georgios Poupouzas
Institutions
- National and Kapodistrian University of Athens (GR)
- Evangelismos Hospital (GR)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Critical Care
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s13054-025-05628-9
- Citations
- 1
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Stavros Niarchos Foundation