The correlation between EGFR mutation status and clinicopathological characteristics, Ki67 expression and immune cell infiltration in lung adenocarcinoma with different radiological subtypes
EGFR mutation rates vary by clinicopathological characteristics and EGFR mutation status significantly influence tumor proliferation and immune cell infiltration in LUAD across radiological subtypes. These findings not only indicate that EGFR mutations may play a crucial role in the progression of GGO-LUAD, but also explain why GGO-LUAD has a better prognosis.
Authors
- Shenghui Qin (ORCID: https://orcid.org/0000-0002-0275-133X)
- Rirong Qu (ORCID: https://orcid.org/0000-0002-3334-3304)
- Shaojie Hu (ORCID: https://orcid.org/0000-0002-1561-422X)
- Xiangning Fu (ORCID: https://orcid.org/0000-0003-4670-1438)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-1317-120X)
- Jing Xiong (ORCID: https://orcid.org/0009-0000-2263-124X)
- Yixin Cai
Institutions
- Hubei Provincial Women and Children's Hospital (CN)
- Wuhan Children's Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s12957-025-03960-6
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Tongji University