Development and validation of a postpartum cardiovascular disease risk prediction model in women incorporating reproductive and pregnancy-related predictors
The updated risk prediction models resulted in marginal improvement in discrimination and calibration compared to QRISK®-3 in postpartum women. This could be due to the known association of pregnancy-related complications with established risk factors of CVD. Although the overall predictive performance and calibration of the updated models was similar, the updated model resulted in better clinical utility.
Authors
- Colin McCowan (ORCID: https://orcid.org/0000-0002-9466-833X)
- Dermot O’Reilly (ORCID: https://orcid.org/0000-0002-9181-0652)
- Krishnarajah Nirantharakumar (ORCID: https://orcid.org/0000-0002-6816-1279)
- Shakila Thangaratinam (ORCID: https://orcid.org/0000-0002-4254-460X)
- Richard D Riley (ORCID: https://orcid.org/0000-0001-8699-0735)
- Steven Wambua (ORCID: https://orcid.org/0000-0003-2300-7670)
- Kym I E Snell (ORCID: https://orcid.org/0000-0001-9373-6591)
- Christopher Yau (ORCID: https://orcid.org/0000-0001-7615-8523)
- Francesca L. Crowe (ORCID: https://orcid.org/0000-0003-4026-1726)
- Sinéad Brophy (ORCID: https://orcid.org/0000-0001-7417-2858)
Institutions
- Queen's University Belfast (GB)
- University of St Andrews (GB)
- John Radcliffe Hospital (GB)
- Swansea University (GB)
- University of Oxford (GB)
- Birmingham Women's Hospital (GB)
- Health Data Research UK (GB)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s12916-025-04229-1
- Citations
- 2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 4.11