Sex disparity in survival outcomes of advanced gastric adenocarcinoma
Males had better OS than females among patients with advanced GAC. In addition, among GAC patients with a mutp53, sex and OS association was inversely driven by the presence of GOF versus non-GOF. Our data reveal a previously unappreciated sex disparity in survival outcomes among patients with advanced GAC. If confirmed, this finding could have important implications for clinical practice and for further understanding the biology of GAC.
Authors
- Pamela Tse (ORCID: https://orcid.org/0009-0005-3494-8320)
- Dean W. Felsher (ORCID: https://orcid.org/0000-0003-2496-523X)
- Laurel A. Habel (ORCID: https://orcid.org/0000-0002-7230-587X)
- Minggui Pan (ORCID: https://orcid.org/0000-0002-8368-6524)
- George A. Fisher (ORCID: https://orcid.org/0000-0002-6828-3938)
- Sachdev Thomas (ORCID: https://orcid.org/0000-0003-3867-2454)
- Ninah Achacoso
- Elaine Chung (ORCID: https://orcid.org/0009-0003-7267-9235)
- Alexander Dang (ORCID: https://orcid.org/0000-0002-7964-7426)
- Jeffrey Y. Bien (ORCID: https://orcid.org/0000-0002-3111-5674)
- Chen Jiang (ORCID: https://orcid.org/0000-0002-0336-4518)
- Vishnu P Kanakaveti
- Meng Tong (ORCID: https://orcid.org/0000-0001-8244-0277)
- Tina Huang (ORCID: https://orcid.org/0000-0003-3818-6894)
- John Stover
Institutions
- Kaiser Permanente (US)
- Kaiser Permanente Vallejo Medical Center (US)
- Kaiser Permanente Santa Clara Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- BJC Reports
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1038/s44276-025-00173-y
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kaiser Permanente