Predictive Factors for HBsAg Seroconversion Following Acute Hepatitis B Virus Infection: A Multicenter BUHASDER Study
Experience with the effect of antiviral therapy on HBsAg seroconversion in acute hepatitis B is limited. We aimed to evaluate the factors affecting HBsAg seroconversion in patients with acute hepatitis B (AHB) receiving antiviral treatment. We performed a retrospective and multicenter study involving 107 adult patients who received antiviral treatment for AHB between January 2018 and December 2023. The median age was 48 (min-max, 18-91) years, and 66.3% of the patients were male; 70 patients with 24-week follow-up (15 patients without HBsAg seroconversion versus 55 patients with HBsAg seroconversion) were compared based on HBsAg seroconversion status. Multivariate logistic regression analysis revealed that age was independently associated with HBsAg seroconversion (odds ratio = 0.926; 95% confidence interval (CI) 0.874 to 0.981; <i>p</i> = 0.009). A one-year increase in age was associated with a 0.926-fold decrease in HBsAg seroconversion. In conclusion, age was an independent predictor of HBsAg seroconversion following acute hepatitis B virus infection.
Authors
- Türkkan Öztürk Kaygusuz (ORCID: https://orcid.org/0000-0002-4151-5903)
- Sıla Akhan (ORCID: https://orcid.org/0000-0002-2540-2060)
- Fatma Yılmaz Karadağ (ORCID: https://orcid.org/0000-0003-4657-5291)
- Gözde Derviş Hakim (ORCID: https://orcid.org/0000-0001-9676-9532)
- Derya Öztürk-Engin (ORCID: https://orcid.org/0000-0002-2566-7317)
- Eyüp Arslan (ORCID: https://orcid.org/0000-0002-5490-465X)
- Süleyman Yıldırım (ORCID: https://orcid.org/0000-0001-9856-3431)
- Müge Toygar Deniz (ORCID: https://orcid.org/0000-0002-6946-2727)
- Burak Sarıkaya (ORCID: https://orcid.org/0000-0002-0026-1927)
- Mehmet Onur Aydoğdu (ORCID: https://orcid.org/0000-0003-4509-3856)
- Semiha Çelik Ekinci (ORCID: https://orcid.org/0000-0002-6264-1685)
- Müge Özgüler (ORCID: https://orcid.org/0000-0002-2689-7931)
- Süleyman Günay (ORCID: https://orcid.org/0000-0002-1159-1577)
- Süleyman Dolu (ORCID: https://orcid.org/0000-0002-7496-9493)
- Selma Tosun (ORCID: https://orcid.org/0000-0001-9844-9399)
- Özlem Bayraktar Saral (ORCID: https://orcid.org/0000-0002-6661-7180)
- Ayşe Batırel (ORCID: https://orcid.org/0000-0002-6005-636X)
- Ömer Karaşahin (ORCID: https://orcid.org/0000-0002-4245-1534)
- Ahmet Rıza Şahin (ORCID: https://orcid.org/0000-0002-4415-076X)
- Tuğba Sarı (ORCID: https://orcid.org/0000-0003-3204-2371)
- Levent Görenek (ORCID: https://orcid.org/0000-0003-3371-7764)
- Derya Seyman (ORCID: https://orcid.org/0000-0002-7451-8537)
- Kemalettin Özden (ORCID: https://orcid.org/0000-0003-3293-5671)
- Serpil Erol (ORCID: https://orcid.org/0000-0001-5655-3665)
- Tuba Damar Çakırca (ORCID: https://orcid.org/0000-0002-1706-230X)
- Özge Çaydaşı (ORCID: https://orcid.org/0000-0003-2804-3101)
- Şükran Köse
- Pınar Yürük Atasoy
Institutions
- Izmir University (TR)
- Fırat University (TR)
- Bilkent University (TR)
- Dokuz Eylül University (TR)
- Izmir Kâtip Çelebi University (TR)
- Gaziantep Children's Hospital (TR)
- Uni Research (Norway) (NO)
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Erzurum Regional Training and Research Hospital (TR)
- Haydarpaşa Numune Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Universidad CES (CO)
- Elazığ Eğitim ve Araştırma Hastanesi (TR)
- Antalya IVF (TR)
- Fatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi (TR)
- Pamukkale University (TR)
- Kocaeli Üniversitesi (TR)
- Gaziantep University (TR)
- Atatürk University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Viruses
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3390/v17091182
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00