Cucurbitacin B from Cucurbitaceae Plants: Treating Pancreatic Cancer via Inducing Mitophagy, Inhibiting Glycolysis, and Enhancing Immune Function
This study, for the first time, reveals that CuB induces mitophagy via the PI3K/Akt/mTOR and PINK1/Parkin pathways to selectively eliminate damaged mitochondria and suppress tumor energy metabolism. CuB inhibits pancreatic cancer through a triple mechanism-inducing mitophagy, inhibiting glycolysis, and activating immunity-which provides innovative insights for pancreatic cancer therapy.
Authors
- Xiaoxv Dong (ORCID: https://orcid.org/0000-0003-1482-7108)
- Xingbin Yin (ORCID: https://orcid.org/0000-0003-3077-1626)
- Jian Ni (ORCID: https://orcid.org/0000-0003-1974-044X)
- Rongrong Chang
- Hongyue Chen (ORCID: https://orcid.org/0000-0002-5663-1464)
- Xiaohong Jing
- Feng Yang (ORCID: https://orcid.org/0000-0003-0769-5573)
- Shuting Lin (ORCID: https://orcid.org/0000-0002-9142-7709)
- Changhai Qu (ORCID: https://orcid.org/0000-0001-6617-1476)
- Dongge Yin
- Yufei Sun
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3390/nu17172809
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35