Precision Oncology Insights into WNT Pathway Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer in High-Risk Populations
Our findings reveal that WNT pathway dysregulation in EOCRC is shaped by ancestry, treatment status, and age. FOLFOX appears to reduce specific WNT alterations in H/L patients and broader WNT disruptions in NHW patients, with survival benefits observed primarily in the latter. These results underscore ancestry-specific molecular responses to chemotherapy and the need for precision oncology strategies tailored to high-risk populations.
Authors
- Francisco Carranza (ORCID: https://orcid.org/0000-0003-1789-4197)
- Enrique Velazquez‐Villarreal (ORCID: https://orcid.org/0000-0002-3603-6414)
- Fernando C. Diaz (ORCID: https://orcid.org/0000-0002-2602-1526)
- Sophia Manjarrez (ORCID: https://orcid.org/0009-0006-0607-1784)
- Brigette Waldrup (ORCID: https://orcid.org/0009-0009-5991-9779)
Institutions
- University of North Carolina at Chapel Hill (US)
- City of Hope (US)
- Beckman Research Institute
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- Cancers
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3390/cancers17172833
- Citations
- 7
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- Comprehensive Cancer Center, City of Hope
- National Institutes of Health