Platelet-derived growth factor-C contributes to kidney inflammation in experimental hypertension with little effect on the peritubular capillary network
Despite influencing certain parameters critical for endothelial homeostasis, such as PDGFR<sup>+</sup> pericyte recruitment following systemic PDGF-C antagonism during hypertension, PDGF-C has minimal effects on the PTC network. Conversely, both systemic and endothelial cell-derived PDGF-C modulate the inflammatory response associated with hypertension in the kidney. Our findings help mitigate safety concerns about pharmacological PDGF-C targeting and its impact on peritubular capillaries.
Authors
- Eva Miriam Buhl (ORCID: https://orcid.org/0000-0003-0627-9228)
- J. Floege
- Rafael Kramann (ORCID: https://orcid.org/0000-0003-4048-6351)
- Eleni Stamellou (ORCID: https://orcid.org/0000-0001-7472-4907)
- Ute Raffetseder (ORCID: https://orcid.org/0000-0002-7236-9793)
- Katja Ermert
- Tammo Ostendorf (ORCID: https://orcid.org/0000-0003-2889-5371)
- C. Dippel
- Ina Verena Martin (ORCID: https://orcid.org/0000-0003-1638-8604)
- Robert Göllinger
Institutions
- University of Ioannina (GR)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Experimental and Molecular Pathology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1016/j.yexmp.2025.104994
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00