Sexually dimorphic associations between Vitamin D metabolites, blood pressure, and placental inflammatory markers in Normoevolutive, preeclamptic and obese pregnancies
Maternal calcidiol levels negatively correlated with BP only in normoevolutive pregnancies. Both OB and PE groups presented elevated pBMI, alongside reduced umbilical cord calcitriol in male-bearing pregnancies, partially explaining the pro-inflammatory/hypertensive signature in their placentas. The results highlight a sexually dimorphic detrimental effect of obesity in placental VD-metabolism, while support the beneficial effects of maintaining an adequate VD nutritional status in pregnancy, particularly when carrying a male fetus.
Authors
- Fernando Larrea (ORCID: https://orcid.org/0000-0003-4431-969X)
- Lorenza Dı́az (ORCID: https://orcid.org/0000-0002-5947-4222)
- Nicolás Salva-Pastor
- Guadalupe Estrada‐Gutiérrez (ORCID: https://orcid.org/0000-0001-9551-9021)
- Janice García‐Quiroz (ORCID: https://orcid.org/0000-0002-3311-2258)
- Euclides Avila (ORCID: https://orcid.org/0000-0003-3063-5093)
- Juan Mario Solís-Paredes (ORCID: https://orcid.org/0000-0003-4529-8296)
- Otilia Perichart‐Perera (ORCID: https://orcid.org/0000-0003-1492-5293)
- Andrea Olmos‐Ortiz (ORCID: https://orcid.org/0000-0002-5456-9695)
- Rafael Vargas-Castro (ORCID: https://orcid.org/0000-0002-3209-1184)
Institutions
- Instituto Nacional de Perinatología (MX)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
Publication Details
- Journal
- Pregnancy Hypertension
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1016/j.preghy.2025.101253
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49