COMPARATIVE ANALYSIS OF BIOCHEMICAL INDICATORS OF CORD BLOOD OF NEWBORN RISK GROUPS REGARDING THE MANIFESTATION OF HEMOLYTIC DISEASE DEPENDING ON THE GROUP AND RHESUS SIGNS INHERITED FROM THE MOTHER

The paper analyzes the interrelationship of a group of biochemical indicators (total bilirubin and its fractions, total protein, albumin, urea, creatinine, uric acid, and glucose) of umbilical cord blood of newborns (103 samples) depending on the group or rhesus trait inherited from the mother. Babies belonged to the risk group for the development of hemolytic disease of newborns without signs of the disease. The determination of the content of the indicators was carried out by standardized unified methods, statistical processing was carried out according to the Mann-Whitney test (for the coincidence of the Rhesus characteristics of maternal and cord blood) and the Kruskal–Wallis test for comparing the average values of three or more samples (for the coincidence of maternal and cord blood groups with each other when inheriting this characteristic). The ratio of groups and rhesus was evaluated according to Fisher's comparative F-test (F-distribution), correlation analysis of indicators was performed according to Pearson's chi-squared test. It is statistically shown that umbilical cord blood with a negative Rh(D) factor is characterized by a significantly higher level of glucose (р=0,046). A significantly higher indicator of the albumin-globulin coefficient is noted (р=0,032) when the group characteristic of umbilical cord blood matches with maternal blood. The content of uric acid in umbilical cord blood from mothers with a negative Rh(D) factor was characterized by a significantly higher value (р=0,024), and the concentration of total bilirubin in such samples, on the contrary, was probably lower (compared to the group of children born from mothers with positive Rh(D)-factor, р=0,023). In addition, the level of uric acid in umbilical cord blood depends on the mother's blood group: its lowest level was noted in umbilical cord blood samples from mothers with 0(I) blood group (p<0.001). Therefore, the concentration of indicators of uric acid, total bilirubin, and glucose depend on the inheritance of group or rhesus traits from mother to child. Key words: umbilical cord blood, biochemical indicators, glucose, uric acid, total bilirubin, albumin-globulin ratio, blood group, Rh(D) factor.