Farrerol confers neuroprotection in spinal cord injury by regulating macrophages/microglia polarization through the JAK2/STAT3 pathway
FAR promotes functional recovery after spinal cord injury by modulating macrophages/microglia M1/M2 polarization through JAK2/STAT3 pathway inhibition, thereby attenuating neuroinflammation and neuronal death. These findings provide novel evidence supporting targeted immunomodulation for SCI treatment.
Authors
- Tao Lu (ORCID: https://orcid.org/0000-0002-3334-8279)
- Jianguo Hu (ORCID: https://orcid.org/0000-0002-9055-874X)
- Yi Yang (ORCID: https://orcid.org/0000-0001-7896-9485)
- Jun Xia (ORCID: https://orcid.org/0000-0001-9308-2188)
- He‐Zuo Lü (ORCID: https://orcid.org/0000-0002-3889-835X)
- Bohan Li (ORCID: https://orcid.org/0009-0003-0318-4327)
- Xue Song (ORCID: https://orcid.org/0000-0002-9610-030X)
- Jing Li (ORCID: https://orcid.org/0000-0002-8168-2466)
- Lü Ren (ORCID: https://orcid.org/0000-0002-6201-8551)
- Yue Chen (ORCID: https://orcid.org/0009-0009-1727-8758)
Institutions
- Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.expneurol.2025.115448
- Citations
- 5
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36