Sex-specific prognostic value of automated epicardial adipose tissue quantification on serial lung cancer screening chest computed tomography
In this large lung cancer screening cohort, serial EAT changes independently predicted CV mortality in women and were more strongly associated with all-cause mortality in women than in men. These findings support routine EAT quantification on chest CT for improved sex-specific cardiovascular risk stratification.
Authors
- Hugo J.W.L. Aerts (ORCID: https://orcid.org/0000-0002-2122-2003)
- Emilia Norton
- I. Langenbach (ORCID: https://orcid.org/0000-0001-7410-0635)
- Borek Foldyna (ORCID: https://orcid.org/0000-0002-2466-4827)
- Marcel C. Langenbach (ORCID: https://orcid.org/0000-0002-8168-2714)
- Matthias Jung (ORCID: https://orcid.org/0000-0001-6808-6494)
- Pamela S. Douglas (ORCID: https://orcid.org/0000-0001-9876-4049)
- Thomas Mayrhofer (ORCID: https://orcid.org/0000-0001-6287-5185)
- Michael T. Lu (ORCID: https://orcid.org/0000-0003-4696-9610)
- Vineet K. Raghu (ORCID: https://orcid.org/0000-0003-3524-3945)
- Jan M. Brendel (ORCID: https://orcid.org/0000-0002-2729-610X)
- Ibrahim Hadžić (ORCID: https://orcid.org/0000-0002-8397-5940)
- Konstantin Nikolaou
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Technische Hochschule Augsburg (DE)
- Duke University (US)
- University of Mannheim (DE)
- University of Augsburg (DE)
- University of Cologne (DE)
- Heidelberg University (DE)
- Cambridge Hospital (US)
- Maastricht University (NL)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Clinical Research Institute (US)
- Dana-Farber Cancer Institute (US)
- University Hospital Cologne (DE)
- Dana-Farber Brigham Cancer Center (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- Mass General Brigham (US)
- University of Tübingen (DE)
- Heidelberg University (US)
Publication Details
- Journal
- European Heart Journal - Cardiovascular Imaging
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1093/ehjci/jeaf257
- Citations
- 2
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- American Heart Association
- AstraZeneca
- Nvidia
- Kowa Company
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Heart, Lung, and Blood Institute